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| 品牌 | absin | 供貨周期 | 兩周 |
|---|
| 概述 | |
|---|---|
| 描述 | CHIR-99021 monohydrochloride is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. |
| 性能 | |
|---|---|
| 保存方法 | -20°C |
| 純度 | ≥98% |
| 分子量 | 501.8 |
| 化學式 | C??H??Cl?N? |
| 分子結構式 |  |
| 溶解性 | DMSO：93 mg/mL (185.33 mM) Ethanol：2 mg/mL (3.98 mM) |
| CAS號 | 1797989-42-4 |
| 外觀 | powder |
| 參考文獻 | |
|---|---|
| [1]. Ring DB et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [2]. Weikel KA et al. Knockdown of GSK3β increases basal autophagy and AMPK signalling in nutrient-laden human aortic endothelial cells. Biosci Rep. 2016 Sep 16;36(5). [3]. Ai Z et al. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One. 2016 Mar 3;11(3) [4]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. [5]. Preston GC et al. Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 2015 Aug 4;34(15):2008-24. | |
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